• nmz787 asked whether any prior art exists for micro- or nanofluidic DNA assembly that incorporates nucleosomes, noting a lack of immediate literature; kanzure recalled an older LC Sciences microfluidic DNA project but confirmed it did not involve nucleosomes.

• A chemistry-only DNA synthesis concept was sketched: a pre-built polymer strand containing removable “caps” between each position is sculpted by selective decapping and nucleotide-addition steps, either photo-chemically (four distinct light wavelengths) or with chemical decapping agents.

• The group discussed applying retrosynthetic design tools to constrain reaction pathways by the energy of single photons in the 300–3000 nm range, and nmz787 suggested borrowing ideas from atomic-layer deposition cycles to achieve monolayer-level control.

• kanzure linked a 2017 eLife paper reporting the first non-invasive MRI visualization of lymphatic vessels in human and non-human primate meninges, confirming earlier rodent findings.

• The 2017 Nobel Prize in Chemistry was highlighted for the development of cryo-electron microscopy; kanzure shared Stanford’s “Getting Started in Cryo-EM” YouTube playlist as an educational resource.

• Eric Topol’s tweet about a Cell Metabolism paper showing fecal microbiota transplants improving insulin sensitivity in a human diabetes trial was circulated, emphasizing microbiome-based therapeutics.

• A biorxiv preprint on “Intercellular mRNA trafficking via membrane nanotubes” was summarized: full-length mRNAs (GFP, β-actin, BRCA1, HER2, etc.) move directly between mammalian cells through actin-dependent membrane nanotubes, potentially altering the recipient-cell proteome.

• UC tech-transfer page for “DNA amplification by electric field cycling” was posted, describing a new PCR-free method that uses oscillating electric fields to drive isothermal DNA amplification.

• nmz787 expressed skepticism about a Science Advances paper claiming “laser streaming,” where a continuous liquid flow is generated from a focused laser spot after nanoparticle-assisted self-etching of a glass cavity.