• A “lossy-template” CRISPR concept was proposed: an 80-bp guide RNA carries only ~8 bp of true targeting information, letting evolved recombinases or polymerases perform the final high-fidelity selection from large DNA libraries as an alternative to full molecular error-correction codecs.

• Rolling-circle amplification, aptamer-primed polymerase reactions, and in-silico PCR were identified as low-cost, high-throughput building blocks for DNA assembly and biosensing workflows.

• Mining the 2017 iGEM Giant Jamboree abstracts surfaced BOKU-Vienna’s “directed in vivo evolution via error-prone reverse transcription” that mutates only the locus of interest, and BostonU_HW’s microfluidic cell-sorting devices.

• Josiah Zayner’s $20 DIY human CRISPR kit (the-odin.com/diyhumancrispr) plus online gRNA-design tools enables non-specialists to target human genes in minutes, triggering debate on safety, regulation, and the ethics of self-modification.

• A wearable “super-hearing” prototype was discussed: 192 kHz MEMS microphones in ear-buds that shift ultrasound/infrasound into the audible range, paired with eye-tracking glasses to isolate speakers in noise; current limitation is 2-hour battery life.

• A new transcript, “DIY human gene therapy with CRISPR,” was published at http://diyhpl.us/wiki/transcripts/diy-human-gene-therapy-with-crispr/ as a resource for open-source gene-therapy funding.

• Channel members argued that gene-drive–based human genocide is implausible: drives would need ~10 generations for demographic impact, and inexpensive USB sequencers (e.g., MinION) make detection and counter-measures straightforward.

• The Odin’s store now lists a “Human Myostatin knock-out CRISPR-Cas9 plasmid” explicitly labeled “not injectable and not for human use,” highlighting the gap between research reagents and DIY human application.

• Genetics of pregnancy-related nausea and vomiting (NVP) were explored: polymorphisms in HTR3C, RYR2, and taste-pathway genes correlate with severity; “cryptic pregnancy” (undetected gestation until labor) was cited as a natural NVP-minimal model for future reproductive-genomics interventions.