- A new “tRiAD” gene-therapy platform combines suppressor-tRNA read-through with ADAR2-mediated RNA editing to correct nonsense and missense mutations in vivo; AAV delivery restored dystrophin in mdx mice and OTC in spfash mice without permanent genomic changes (bioRxiv 210278).  
- Recent Nature and Science papers describe an evolved adenosine-deaminase base editor that converts A→I (read as G) in DNA, complementing Liu lab’s C→T system and enabling true A•T→G•C corrections.  
- MouseLight (mouselight.janelia.org) was introduced as an open, whole-brain, single-neuron morphology database, and a simulation study proposes combining expansion microscopy with in-situ barcoding and CNN segmentation for all-optical dense-circuit reconstruction.  
- BGI has launched the George Church Institute of Regenesis to scale industrial synthetic-genomics capacity, while a GP-write working group is drafting a call to determine when de-novo genome synthesis becomes cheaper than iterative editing, with a public Google Doc collecting DNA-synthesis techniques and polymerase specs.  
- A public Google Sheet now catalogs template-dependent and template-independent polymerases (TdT, telomerase, poly-A polymerase) for enzymatic DNA synthesis, and participants debated rare polymerases capable of template-independent extension, citing a 2004 paper on thermophilic polymerase/restriction-enzyme synergy.  
- A Nature paper overturns marrow-centric thrombopoiesis by showing mouse lungs produce ~50 % of circulating platelets and contain hematopoietic progenitors.  
- DIY-bio updates include Chicago biohackers acquiring an electrophoresis power supply and Gizmodo coverage of patient-led DIY CAR-T immunotherapy.  
- Participants explored using swarms of LED/sensor-equipped micro-robots as physical analogues of amino acids to accelerate protein-folding simulation, though skepticism was voiced about outperforming optimized numerical methods.  
- Enzyme-stabilization literature was shared showing Taq polymerase and restriction enzymes remain active for weeks to months at ≤50 °C, enabling ambient-temperature diagnostics.  
- Links circulated for the gdsCAD Python package (GDSII mask generation) and a Foresight Institute article on de-novo protein design toward programmable nanoscale machinery.