• DNA-PAINT combined with spinning-disk confocal microscopy now enables whole-cell, gigadalton-scale 3-D super-resolution imaging, as reported in a new Nature paper and Wyss/LMU press release.  
• Two adjacent Nature papers—“Programmable self-assembly of three-dimensional nanostructures from 10,000 unique components” and “Biotechnological mass production of DNA origami”—mark a major leap toward industrial-scale scaffolded DNA origami.  
• Gilead’s $567 M acquisition of Cell Design Labs and Arzeda’s $15.2 M Series A led by OS Fund signal a coming wave of M&A and venture investment in gene-, cell-, and protein-engineering platforms.  
• A continuous-flow, low-voltage electroporation device using serpentine microfluidic channels with in-situ polymerized conductive hydrogel electrodes significantly improves membrane permeabilization efficiency (APL paper).  
• Reversing glutaraldehyde cross-links for aldehyde-stabilized cryopreservation remains an open problem; participants debate the need for membrane-permeant enzymes or selective chemical cleavage and the trade-off between methionine cross-link density and degradation.  
• TdT-based enzymatic DNA synthesis is questioned due to the absence of published sequence data for long strands; rumors suggest DNA Script and DNAsCRIPT may use unnatural nucleotides but keep results in patents.  
• SingularityNET’s ICO reportedly raised ~$36 M (not the rumored $150 M) for decentralized AI services, with participants expressing skepticism about Ben Goertzel’s project.  
• Robert McIntyre (Nectome) continues brain vitrification work, while the channel jokes about a “grave-robbing aldehyde perfusion pipeline” for whole-brain preservation.