- DNA data-storage density: practical schemes under discussion achieve ~1 bit per 100 base pairs, with theoretical limits for human-genome compression closer to 1 bit per 500–1 k bp; VCF and other sparse formats can do far better by omitting identical chromosomes.  
- Brain-uploading scale estimate: ~10^20 distinct objects (neurons, synapses, receptors) must be bar-coded; 36-bp DNA barcodes would require ~10^21 unique molecules, prompting discussion of whether engineered DNA-processing throughput could exceed the biosphere’s ~10^24 bp s⁻¹.  
- Imaging throughput debate: electron-microscopy (EM) approaches (Halcyon Molecular’s one-EM-year-per-brain estimate) are compared with massively parallel nanopore sequencing and DNA-nanoscopy schemes; bulk chemistry reactions may out-perform raster-scanning EM or focused-ion-beam milling.  
- Recent DNA-nanotech papers highlighted: “DNA nanoscope via auto-cycling proximity recording” (Nature 2017), “Programmable autonomous synthesis of single-stranded DNA” (Yin lab), and multiplexed 3-D super-resolution with DNA-PAINT for whole-cell imaging.  
- Directed-evolution proposal: evolve nanopore proteins for higher speed and fidelity to push sequencing toward the exotic 10 Mb s⁻¹ per-pore regime.  
- DIY biology resources: links to diyhpl.us/wiki/diybio/faq and diyhpl.us/wiki/genetic-modifications/ for home tissue-culture, laminar-flow-hood builds, and gene-function annotations.  
- Bitcoin-forking tool: Forkgen (Bitcoin Magazine article) lowers the barrier to launching new Bitcoin forks, continuing the channel’s long-standing interest in cryptocurrency funding for open biotech.  
- Integrated Space Plan podcast: Jay Wittner & Josh Powers interviewed on The Space Show (19 Dec 2017 episode) was shared as relevant long-term infrastructure context.