- A new Medium interview with Aubrey de Grey was circulated (https://medium.com/@arielf/wake-up-people-its-time-to-aim-high-b0c2bcac53f1), noting that he donated ~$13 million of a $16.5 million inheritance to SENS research in 2011.  
- Discussion of CRISPR safety: a tweet-thread (https://twitter.com/antonioregalado/status/949346038833434624) highlighted a pre-print warning that many humans already have adaptive immune responses to Cas9, potentially blocking or even causing toxicity in CRISPR therapies.  
- Ultrasound was proposed as a less invasive alternative to needles for transient, reversible opening of the blood–brain barrier (BBB) to deliver therapeutics.  
- A new longevity-focused venture, Ascendance (http://ascendance.io/), was introduced; participants were invited to critique it. It appears to be run by the same team behind Inovium Rejuvenation (https://inoviumrejuvenation.com/about-us).  
- Channel operator kanzure reported that all of his passwords had been compromised and provided SHA-256 hashes of the day’s IRC log archive and checksum file for integrity verification.