- A new PNAS paper on “Mechanogenetics for the remote and noninvasive control of cancer immunotherapy” was shared; it describes engineering T-cells with the mechanosensor Piezo1 so that focused ultrasound can switch on chimeric-antigen-receptor expression with high spatiotemporal precision, raising the question of why not simply ablate tumors with the same ultrasound instead.  
- Discussion of ultra-long-term data storage for cryonics: darsie outlined a goal of preserving mind-state information for up to 1,000 years in an autonomous cryo facility, and nmz787 estimated that the HD-Rosetta process (20-nm features) could store ~4 GB in 3–6 days, though this resolution exceeds what a “simple” microscope could read.  
- nmz787 disclosed employment at the company that produces the HD-Rosetta archival medium and offered further technical assistance or custom work.  
- kanzure reported that an outside party is seeking an exclusive agreement for his “designer baby” research proposal, hinting at early commercial interest.  
- A transcript of Andrew Poelstra’s 2018 Real World Crypto talk on “Mimblewimble and Scriptless Scripts” was committed to the diyhpluswiki repository, providing a detailed technical reference on privacy-preserving blockchain scripting techniques.