- Bitmain’s quarterly revenue to TSMC reportedly matched nVidia’s, highlighting the scale of cryptocurrency ASIC demand.  
- A pitch deck circulated for a “low-cost human designer baby” project forecasts ~1 million genetically-edited births by 2045, with discussion focusing on reducing mutational load and removing rare deleterious variants.  
- Bram Cohen outlined two practical editing strategies: (1) purge very rare, likely harmful mutations to cut overall genetic load, and (2) investigate ~2,000 rapidly spreading variants whose functions remain unknown.  
- Walter De Brouwer noted that fully-sequenced human genomes (including exomes) already exceed 2 million and are doubling yearly, providing an expanding data set for variant-effect analyses.  
- A Wall Street Journal article was shared describing China’s accelerated gene-editing clinical trials, emphasizing fewer regulatory constraints compared to Western jurisdictions.  
- Conversation turned to engineering “happier babies” who cry less, framed as a way to reduce parental stress, shaken-baby syndrome, and possible downstream cognitive deficits linked to persistent colic.  
- Participants debated whether colic is primarily organic (e.g., GERD, allergies) or behavioral, citing studies showing <5 % of excessive crying has an identifiable medical cause.  
- Long-term cognitive data were referenced: children with prolonged crying (not just colic) scored ~9 IQ points lower than controls, hypothesized to result from reduced environmental feedback and learning opportunities.  
- Ethical and evolutionary questions were raised about parental bonding, societal pressure to love all offspring equally, and the prospect of artificial wombs enabling fine-grained control over gestational environment and traits.  
- Links to literature on the KIBRA gene and working-memory enhancement were posted, alongside mentions of Greg Egan’s and Ted Chiang’s fiction exploring engineered aesthetics and parental choice.