• SciHouse, a DIY biohacker space, was debated—kanzure suggested it pivot toward muscular-dystrophy gene-therapy projects and later polled the channel on whether the effort should be “nuke[d] or keep[t].”

• A $2.4 million Ethereum donation to the SENS Research Foundation by Vitalik Buterin was announced, prompting a critique from jrayhawk that SENS projects focus on superficial downstream effects rather than root metabolic causes of aging.

• Recent literature shared included a 2017 review on non-viral gene-therapy vectors in China and a Springer paper describing CRISPR-dCas9 activation of the anti-aging/cognition-enhancing gene Klotho.

• DARPA’s BTO director presented at BDYHAX2018 on neurotechnology and pandemic-prevention biotech; conference photos showed DIY gene-therapy discussions with Meow-Ludo Meow-Meow and Liz Parrish, plus Stelarc’s 1980 “third hand” cyborg performance.

• OpenAI released “Requests for Research 2.0,” a list of open problems aimed at both newcomers and experienced practitioners in AI safety and capability research.

• Bulletproofs cryptographic protocol code and a Schnorr-signature explainer were linked as part of ongoing blockchain-security engineering work.

• CircuitPython/MicroPython hack-chat logs were circulated for embedded-hardware developers interested in rapid bio-device prototyping.

• kanzure solicited suggestions for single-nucleotide metabolic upgrades compatible with AAV delivery, with MTRR/MTHFR and ApoE polymorphisms mentioned as candidate targets.