- MICrONS-scale connectomics: Dan Bumbarger (MICrONS team) reported that their 5-parallel SEM pipeline will image at ~4 nm resolution with 40 nm section thickness, generating ~25 TB/day; a competing team using Zeiss 64-beam multi-beam SEM is expected to reach similar effective rates (~100 TB/day).  
- Sci-Hub infrastructure details: The Verge article revealed that Sci-Hub’s master server once lived in a Russian dorm room with 13 hard drives; LibGen lost 40 k papers when an admin died and the domain lapsed.  
- Open-access legal front: Elsevier and ACS have obtained UK/US court injunctions forcing ISPs to block LibGen, Bookfi, Ebookee, etc., and are demanding Cloudflare hand over operator logs.  
- DIY-bio controversy: Ascendance Biomedical CEO Tristan Roberts locked himself in the lab after self-testing a DIY herpes therapy; team members walked out, and a transcript of the incident was posted to diyhpl.us.  
- Inter-species gamete engineering discussion: Participants explored using somatic-cell nuclear transfer (SCNT) into enucleated oocytes from non-human mammals to create “customized” human gametes, noting low efficiency (3–5 %) and developmental issues.  
- Memory-encoding speculation: nmz787 raised the idea that memory might be stored in microtubules, requiring <1 nm³ cryo-EM resolution for upload fidelity; kanzure dismissed it as “quantum woo-woo.”  
- Centralized-ledger anti-fraud proposal: kanzure outlined a “scorched-earth” design where any operator fraud must be an explicit on-ledger transaction, allowing users to burn all coins via fraud proofs and migrate to an honest fork.