- A new pre-print (bioRxiv 265231) presents an end-to-end differentiable model that predicts 3-D protein structures directly from sequence, potentially eliminating the need for separate folding simulation steps.  
- Channel members explored using AAV or lentiviral vectors to transiently over-express or silence key lipolytic enzymes (HSL, ATGL/desnutrin, perilipin, LPL) and proposed inducible promoters to toggle insulin production or hepatic glucose uptake as a reversible metabolic “switch.”  
- SGLT2, the renal glucose transporter, was proposed as a CRISPR target for adipose-specific knock-down to increase urinary glucose loss; mouse knockouts already show resistance to diet-induced obesity.  
- A literature review mapped the regulatory network around ATGL (PNPLA2), showing that its activator ABHD5/CGI-58 and inhibitor G0S2 fine-tune lipolysis, while over-expression of desnutrin itself drives fatty-acid oxidation and leanness.  
- Caveolin-1-deficient, UCP1-deficient, Ren1c-deficient, and ghrelin-receptor-knockout mice were all cited as gene-knockout models that confer unexpected resistance to diet-induced obesity, highlighting the complexity of metabolic control.  
- Capsaicin and glycyrrhizic acid were noted as topical or dietary agents that up-regulate lipolysis, with users half-seriously discussing DMSO-based delivery methods from body-building forums.  
- The mitochondrial uncoupler 2,4-dinitrophenol (DNP) was reviewed for its 1930s–1980s clinical use in weight loss, its associated fatalities, and the FDA injunction that ended its legal availability.  
- Kanzure circulated a tongue-in-cheek list of “impossible” DNA-synthesis goals requested by GP-Write—such as gas-phase DNA lasing and in-vivo programmable synthesis—to provoke creative roadmap thinking.