• Capsaicin pharmacology: an 8 % prescription patch costs ≈ $800, yet grocery-store chili extract is <$10, illustrating extreme health-care cost disease; topical capsaicin was reported to markedly reduce local fat levels.

• Metabolic-rate genetics: discussion centered on FTO gene variants (rs17817449), the glucogenic hormone asprosin (C-terminal fibrillin-1 cleavage product), and rare lipodystrophy syndromes that force patients to consume 5 000–8 000 kcal d⁻¹ yet remain lean.

• Adipocyte-focused interventions: participants considered down-regulating adipocyte-specific lipogenesis, using SGLT2 inhibitors, and over-expressing desnutrin/ATGL to increase thermogenesis and oxygen consumption in white adipose tissue.

• Skin aging & hormesis: a mouse study showed that topical dilute bleach (NaOCl) blocks NF-κB, reverses age-related skin thinning, and increases cell proliferation, whereas H₂O₂ did not replicate the effect.

• 4-D printing for regenerative medicine: a linked review paper describes shape-memory and solvent-/time-responsive polymeric scaffolds intended for custom tissue and organ regeneration.

• CRISPR patent landscape: commentary claimed MPEG LA holds no foundational CRISPR IP; key Cas9 and Cpf1 patents are controlled by Berkeley, Vienna, and the Broad Institute, with smaller portfolios at Editas, Intellia, and CRISPR Therapeutics.

• Lightning Network & discreet log contracts: shared links to Thaddeus Dryja’s Dev++ talk and a newly disclosed “secret-size attack” on cross-chain hash-lock smart contracts.

• Miscellaneous tools: a GitHub project (polychip) that extracts NMOS netlists from Inkscape SVGs was noted, alongside the purchase of the textbook “Electrokinetically-Driven Microfluidics and Nanofluidics.”