- GP-write issued a call for “dream technology suggestions” for DNA delivery; participants proposed complete mammalian-cell transfection, optically-gated natural-competence pores, bacterial nanoneedles, transfection-helper genes that boost electroporation/lipofection efficiency, and making mammalian chromosomes non-essential so only small DNA fragments need delivery.  
- Bench biologists reported that manual microinjection into mammalian nuclei is labor-intensive and limited to ≈500 kb because of claimed DNA shear; the channel debated automating the process with computer-vision-controlled nanopositioners and questioned whether slower, multi-hour injections could circumvent the size limit.  
- Alternative delivery concepts discussed included magnetofection (magnetic nanoparticles dragged into cells by permanent magnets), microfluidic encapsulation of single DNA molecules in dissolvable magnetic microparticles, laser-propelled microbeads fired directly into nuclei, and repurposing intracellular parasites or eukaryotic algae with strong homologous-recombination machinery to ferry DNA.  
- A study on “resetting the yeast epigenome with human nucleosomes” was highlighted: yeast engineered to use human histones revealed conserved chromatin-remodeling networks, higher DNA occupancy, slower adaptation, and a platform for studying histone variants via epigenome reprogramming.  
- Roswell Biotechnologies’ Electronic Nano-Device Sequencing (ENDSeq) chip—10 nm sensors that read polymerase-mediated base incorporation via changes in molecular-electronic current—was noted; participants felt the company under-appreciated non-sequencing applications of the technology.  
- Self-cloning marbled crayfish spreading across Europe was shared as a real-world example of asexual self-replication, prompting curiosity about edibility and ecological impact.  
- The channel linked a legal analysis of the new Blockchain Defensive Patent License under which ASICBOOST will be licensed for defensive use, and a New York Times article on the invasive crayfish.