• The Brain Preservation Foundation awarded its Large-Mammal prize to 21CM and Nectome for Aldehyde-Stabilized Cryopreservation (ASC), a fixation-plus-vitrification protocol that preserves the full connectome; Ken Hayworth’s essay “Vitrifying the Connectomic Self” argues ASC is ready for medical adoption.  
• Channel participants debated technical fixes for cryogenic fracturing—liquid-methane cooling, pressurized nitrogen annealing, and electrically controlled temperature ramps—while noting that today’s best practices already minimize cracks.  
• A consensus emerged that “brain uploading,” “memory preservation,” and “brain emulation” are distinct goals; preserving the physical substrate is a prerequisite, but downstream uses range from static memory extraction to full emulation at any speed.  
• Near-term commercial applications for early molecular nanotechnology were proposed: diamond-lattice quantum-computer qubit arrays, nanoparticle/aptamer blood diagnostics, single-nanofactory precision sensors, and DNA-origami-guided carbon-nanotube extruders, all anchored in Drexler’s Nanosystems scaling laws and the Merkle-Freitas minimal toolset.  
• James Clements’ Betterhumans project released whole-genome sequences of ~36 supercentenarians; GWAS hits near CDKN2B/ANRIL, SH2B3/ATXN2, ABO, and HLA were noted, with cloning of centenarian genomes suggested as a more actionable longevity experiment.  
• Nectome confirmed it has already chemically preserved one human brain under a terminal-use protocol, reigniting debate over the ethics and marketing of “100 % fatal” mind-uploading services.  
• The Pacific Fertility Center’s loss of ~5,000 cryopreserved eggs/embryos due to a single dewar failure prompted discussion on redundant monitoring, fail-safe design, and post-failure disclosure ethics.  
• Participants critiqued the circular logic of developing gene drives as a defense against gene drives, questioned why such drives are absent in nature, and referenced the “krogan genophage” meme to highlight how defense agencies borrow science-fiction tropes for biosecurity narratives.