• A Wired article on “synthetic human genomes” was critiqued for conflating DNA storage with immortality and for mis-explaining the GP-write recoding work; kanzure argued that single-chromosome recoding is unlikely to grant broad virus resistance because the remaining tRNA synthetases would still be vulnerable.

• kanzure floated the idea of repurposing CRISPR-Cas9 bacterial immune systems as a partial antiviral strategy for human cells, noting that absolute resistance is unrealistic but “fun things” could be done.

• A PNAS paper on “Precise Cas9 targeting enables genomic mutation prevention” was shared, along with its Wyss Institute press release, as an example of using CRISPR to proactively block new mutations.

• Multiple high-throughput neuroscience links were posted: automated synapse-level connectomics pipelines, Harvard’s Neuroglancer WebGL volumetric viewer, and a series of talks on thalamocortical circuits and asteroid-impact early-warning systems.

• Discussion of DIY estrogen synthesis referenced the “Estrofem! Lab (2016)” guide (maggic.ooo) and a failed attempt at a bioluminescent yeast estrogen assay (BLYES), highlighting practical gaps in garage biohacking such as contamination control and MTA barriers.

• A MATLAB/Octave GDSII toolbox for designing micro- and nano-lithography layouts (MEMS, photonics, microfluidics) was circulated as a useful open-source layout tool.

• Numenta’s “Thousand Brains Model of Intelligence” blog post was dismissed as “fluff,” questioning the community’s enthusiasm for the company’s output.

• Emily Leproust’s tweet thread on DNA data storage was noted, emphasizing initial use-cases in cold archival storage (medical records, media, financial data) rather than latency-sensitive applications.