• MIT cut ties with Nectome after neuroscientists declared its “fatal brain-uploading” premise impossible; the full 2018 Nectome presentation transcript is archived at http://diyhpl.us/wiki/transcripts/nectome-1517-2018/.

• Participants compared cryopreservation quality: Alcor’s decades-old protocols produce extensive EM-visible neuronal damage, whereas Nectome’s aldehyde-based fixation preserves superior ultrastructure.

• Recent bioRxiv preprints shared in-channel include DNA-based AND logic in mammalian cells, single-nucleotide-resolution living-cell memory, CRISPR/CRISPRa “synthetic species” reproductive barriers in Drosophila, and a theoretical multi-layer biomolecular electronic computer.

• UK Biobank completed whole-genome sequencing of its first 50 000 participants, releasing open-access genomic data for longevity and disease research.

• Open Philanthropy granted $11.3 M to the University of Washington’s Institute for Protein Design to advance de-novo protein engineering and synthetic-biology tools.

• A geo-engineering paper proposed freezing CO₂ “snow” from Antarctic air at 133 K using wind power; back-of-the-envelope calculations questioned the net energy balance and scalability.

• GenSight’s Phase-III gene-therapy trial for Leber’s optic neuropathy failed when the placebo eye improved as much as the treated eye, prompting debate over cross-eye biological effects or flawed trial design.

• Community resources include permanent public logs at http://gnusha.org/logs and an open-source transhumanist knowledge base at http://diyhpl.us/wiki.