- A call went out for open-source repositories of 3-D-printable prosthetics or human-enhancement devices; Thingiverse was noted as surprisingly sparse and a pointer was given to the prosthetics work being done at Nova Labs.  
- kanzure shared the pre-print “Toward machine-guided design of proteins” (biorxiv.org/337154) and its announcement tweet, highlighting the accelerating use of AI for de-novo protein engineering.  
- A deep technical discussion on cholesterol and statin therapy unfolded: participants argued that LDL-cholesterol is a poor proxy for cardiovascular risk, that ApoB100 or LDL-P are better biomarkers, and that statins reduce heart-attack incidence but may worsen quality-adjusted life years (QALYs) by inhibiting steroid-hormone and membrane synthesis.  
- jrayhawk linked to an extreme dietary self-experiment at cholesterolcode.com that documents a precipitous drop in LDL-C, framed as a cautionary tale about how current clinical metrics may mislead both patients and insurers.  
- kanzure posted Dan Boneh’s Black Hat talk “Bugs in crypto implementations” (YouTube link) as a reminder that subtle implementation flaws continue to plague cryptographic software—a concern relevant to secure transhumanist and bio-data projects.