- kanzure proposed a multiplexed, TET-inducible genetic-circuit toolkit: pre-load every cell in the body with a library of genetic circuits, then use combinations of small-molecule or optogenetic triggers to up- or down-regulate chosen genes only in the cell populations you want, effectively giving on-the-fly, cell-type-specific reprogramming without further gene delivery.

- To ensure only correctly-targeted cells survive, he suggested coupling the system to programmed cell death during in-utero development: cells that never receive the activation chemistry undergo apoptosis, pruning the organism to the desired, precisely-edited subset.

- Discussion of limb-size genetics referenced classic salamander transplant data showing limb size is genetically fixed, plus a new axolotl study (PMC5707178) demonstrating that repeated early removal of limb buds permanently reduces final appendage size, implying developmental “memory” of growth cues.

- gwern.net’s “Embryo editing for intelligence” article was circulated, alongside a DIY-bio radio segment (SCPR) debating democratization vs. safety of citizen science, and a PNAS paper on “sparse bursts” as an energy-efficient neural coding strategy.

- Tangential links included George Church’s lab as the go-to source for Woolly-mammoth cells (per a bio-design competition), Anders Sandberg’s “dissolving the Fermi paradox” essay, and NuSI post-mortems on failed nutrition-science reform.