• CRISPR lineage-tracing in mammalian embryos: new work shows CRISPR can record a cell-by-cell developmental history inside an embryo, offering a powerful tool for mapping early mammalian development.  
• Senolytic life-span extension: Oisin Biotechnologies released mouse data demonstrating significant life-span increases via targeted clearance of senescent cells, reinforcing the therapeutic potential of senolytics.  
• JNK inhibition for muscle growth: recent findings identify JNK pathway suppression as a promising route for enhancing muscle hypertrophy and countering age-related sarcopenia.  
• Tau removal boosts cognition: experiments in young mice show that lowering tau protein levels improves brain function, suggesting tau-targeting therapies could enhance cognition even before overt neurodegeneration.  
• Repair Biotechnologies closed a seed round and joined the Grapeseed Bio incubator, signaling growing investor interest in early-stage longevity biotech.  
• Naked-mole-rat biochemistry updates: new papers dissect the molecular adaptations underlying their exceptional longevity and cancer resistance, providing candidate genes for human gene-therapy approaches.  
• Upcoming conferences: Undoing Aging 2019 (Berlin, 28–30 March), Berkeley Aging Research & Technology symposium (16–17 Aug), RAAD Festival San Diego (20–23 Sep), and TransVision Madrid (19–21 Oct) will gather researchers and biohackers to advance open discourse on life-extension science.  
• Octopart now supplies downloadable CAD models for electronic components, streamlining open-hardware prototyping workflows.