- The channel discussed the FDA’s 2017 landmark approval of pembrolizumab (Keytruda) for any unresectable or metastatic solid tumor with mismatch-repair deficiency or microsatellite instability—the first cancer drug approved on genetic rather than tissue criteria.  
- Participants shared and compared Sci-Hub mirror URLs (cyber.sci-hub.tw, backup.sci-hub.tw, dacemirror.sci-hub.tw) and noted differences in how articles are addressed (base64 vs. MD5 hashes).  
- A 16 GB “snapshot” from Unpaywall.org was examined and found to contain only Crossref DOI metadata, prompting criticism that it lacks the actual PDFs needed for open access.  
- Links to large-scale open-access resources were circulated, including the Library Genesis torrent repository (gen.lib.rus.ec/scimag/repository_torrent/) and the Unpaywall Google Group for dataset updates.  
- A 2012 Humanity+ San Francisco talk titled “Project Nemaload” by David A. Dalrymple was surfaced, along with a request for Alexandra Elbakyan’s lost 2010 Harvard talk on consciousness.  
- The password manager “pass” (passwordstore.org) was recommended as a secure credential tool.  
- A brief speculative tangent considered underground construction as a workaround for San Francisco’s refusal to build upward or seaward.