- A pre-print PDF on PCSK9 gene editing in human embryos was shared: https://www.statnews.com/wp-content/uploads/2018/12/He-manuscript-on-PCSK9-in-embryos_p1.pdf.  
- Concerns were raised about the cancer risk of injecting “immortalized” cell lines, noting that even trace telomerase gene transfer from culture medium could eventually trigger tumors—though participants judged this risk preferable to dying of old age.  
- The Agex Inc. technology page (https://www.agexinc.com/technology/) was linked as a reference for cell-rejuvenation approaches.  
- Extended discussion on magnesium supplementation compared magnesium L-threonate (reported to give subtle mellowing and better sleep) with magnesium glycinate; both were chosen for high bioavailability, but daytime use caused drowsiness.  
- Practical tips emerged: magnesium-induced drowsiness can be blunted by co-ingesting calcium or milk, yet whole milk’s saturated fat may reduce absorption; calcium supplementation should be paired with vitamin K2 to avoid harm.  
- Users in the EU noted customs/VAT hassles when ordering nootropics or supplements from the United States.  
- A BMJ satirical RCT on parachute use (“Parachute use to prevent death and major trauma when jumping from aircraft”) was highlighted as an example of “troll epistemology” in evidence-based medicine.