- A curated set of 181 “intelligence-related genes” (IRGs) drawn from GWAS and literature was analyzed; pathway enrichment shows strongest involvement of Wnt signaling in general tissue, while brain-specific IRGs point to G-protein–coupled and dopamine-mediated signaling cascades.  
- DRD4 promoter variant rs3758653 is highlighted as reproducibly associated with perceptual-speed performance in >1,000 cognitively healthy Europeans, with prior smaller Chinese cohort data corroborating the effect.  
- DAB1, an adaptor in the Reelin pathway, is noted for its correlation with dendritic-spine density and improved associative/spatial memory, positioning it as a candidate for cognitive enhancement interventions.  
- Archived datasets from the now-offline “IQdb” (gene_list.txt, core_dataset.txt, snp.html) were recovered via Wayback Machine and linked, providing a historical compendium of SNP–IQ associations.  
- Recent papers on infant cognitive ability, dyslexia locus 2p12, and a dopamine-receptor variant enhancing processing speed were shared, underscoring convergent molecular targets for intelligence augmentation.  
- Commentary emphasized that engineering dopamine receptors with 1,000-fold higher affinity is considered “trivial” with current molecular-biology techniques, framing receptor tuning as a near-term enhancement lever.