• A new transcript of Andrew Poelstra’s talk on “Signature-scheme security properties” from MIT Bitcoin Expo 2019 was posted at http://diyhpl.us/diyhpluswiki/transcripts/mit-bitcoin-expo-2019/signature-scheme-security-properties/.

• The transcript for the “Utreexo” presentation (scalable Bitcoin UTXO accumulator) from the same conference was also added, along with a back-reference to the speaker’s Twitter account.

• ArchiveBox, an open-source self-hosted web archiving tool (https://github.com/pirate/ArchiveBox), was shared as a resource for preserving web content relevant to research and documentation.

• A pre-print describing whole-exome sequencing of 49,960 UK Biobank participants was highlighted: it catalogs ~4 million coding variants (98.4 % with frequency < 1 %), 231,631 predicted loss-of-function variants, and notes that >97 % of genes harbor at least one loss-of-function carrier (https://www.biorxiv.org/content/10.1101/572347v1).

• Brief speculative discussion touched on thermodynamic interpretations of biological time and cancer progression, suggesting that “brain cancer only travels along one ray of a thermodynamic geodesic” and that such geodesics might be delineated biochemically.