- In 2012 the FBI opened an investigation into #hplusroadmap participants over fears they were “making viruses,” assigning each member an agent who met with them weekly until the Bureau concluded they were harmless; a full transcript of the 2012 FBI–DIYbio meeting is available at http://diyhpl.us/wiki/transcripts/fbi-diybio-2012/.

- Channel members confirmed they had personally experimented with CRISPR and pointed to David Ishee’s genetically modified mice as one visible outcome of those efforts.

- Discussion referenced Alexander Shulgin’s lab visits by federal agents, noting that the chemist politely offered food and water while agents, following paranoid Cold-War-era protocols, refused everything for fear of covert intoxication.

- Participants debated the practical limits of waterproofing outdoor biohacking gear, concluding that in Mediterranean climates it is more effective to design for controlled wetness (e.g., sealable food-grade boxes for electronics) than to rely on dubiously effective waterproof membranes.

- MoltenVK, an open-source Vulkan-on-Metal translation layer released by the Khronos Group, was highlighted as a key tool for bringing high-performance graphics and compute to macOS and iOS devices.

- A George Church talk titled “The Future of Genetic Engineering” from the Hello Tomorrow Global Summit 2019 was circulated, along with appearances by biohackers Josiah Zayner and journalist Antonio Regalado.