• A pre-print on bioRxiv analyzes the statistical likelihood that the genetic genealogy search used to identify the Golden State Killer would succeed, providing a rare quantitative look at forensic genomics methods (https://www.biorxiv.org/content/10.1101/531384v1).

• Juvenescence Ltd. announced a $3 million investment in LyGenesis, whose experimental therapy injects autologous hepatocytes into lymph nodes to grow ectopic “mini-livers” as an alternative to whole-organ transplantation for end-stage liver disease.

• Discussion highlighted that a large share of modern hepatic pathology may stem from choline deficiency, leading to impaired phospholipid and lipoprotein synthesis that prevents clearance of hepatically converted fatty acids; participants pointed to a body of literature on choline and hepatic steatosis (https://scholar.google.com/scholar?q=hepatic+steatosis+choline).

• A container-centric bioinformatics workflow paper titled “Container-based bioinformatics with Pachyderm” was shared, describing reproducible, version-controlled pipelines for large-scale genomic analyses (https://www.biorxiv.org/content/10.1101/299032v1).

• The diyhpluswiki repository was updated with a transcript of Tom Kirkpatrick’s 2018 Lightning Hack Day talk on the Zap Lightning Network wallet, continuing the channel’s practice of archiving open-source and decentralization-oriented technical content (http://diyhpl.us/diyhpluswiki/transcripts/lightning-hack-day/2018-12-01-tom-kirkpatrick-zap-wallet/).