• The channel debated the plausibility of near-term limb regeneration: while some participants argued it is “likely this century,” others emphasized that assembling a functional limb from cultured tissue is still far off because nerves must grow several feet, sterile culture is hard, and pluripotent-cell remnants risk teratomas.

• fenn outlined a speculative scaffold-and-bud approach: 3-D-printing biocompatible hydrogel scaffolds, seeding them with multiple cell types, guiding self-organization with growth-factor gradients and electric fields, and implanting a “tiny bud” that would still need years to mature and integrate with the host.

• archels noted that progress is slowed by the lack of researchers specifically targeting limb regrowth, and suggested that only the serendipitous discovery of an epigenetic “master switch” from highly regenerative species such as lizards could accelerate the field.

• kanzure circulated a draft open letter to the WHO urging a permissive stance on clinical germline genetic engineering; the letter and related tweets were archived at diyhpl.us and discussed as part of ongoing advocacy for responsible human genetic modification.

• Links shared for further reading included a Nature Human Behaviour paper on public attitudes toward gene editing (doi:10.1038/s41562-019-0651-1), a satirical “press release from the future” on consumer embryo engineering, and a Baylor College of Medicine blog post warning that DIY biohacking may be reclassified as practicing medicine.

• nmz787 highlighted a new cryo-focused-ion-beam (cryo-FIB) lift-out technique that enables molecular-resolution cryo-electron tomography inside intact C. elegans tissue, accompanied by a Twitter video showing the worm being frozen, milled, and extracted for imaging.