- A new Nature paper (Fahy et al., 2019) reports the first evidence of biological-age reversal in humans: 9 volunteers given a year-long thymus-regeneration cocktail (growth hormone, DHEA, metformin) showed an average 2.5-year rollback on Horvath’s epigenetic clock, with immune-cell rejuvenation as a plausible mechanism.  
- Discussion highlighted that the real novelty is not merely that epigenetic age can differ from chronological age, but that the clock is now precise enough to detect a statistically significant reversal after an intervention.  
- A PubMed study (PMID 30458175) describes an unbiased forward-genetic screen that uncovered ten mouse genes conferring resistance to cryoprotectant toxicity (M22 and DMSO); the most potent mutant (Gm14005 insertion) improved post-thaw survival 12.7-fold, implicating MYC signaling and several previously unknown pathways.  
- The Wikipedia article “Information-theoretic death” was gutted by an administrator, sparking debate over systemic bias against cryonics and other “fringe” longevity topics; participants argued that mainstream sourcing standards are being applied selectively.  
- Bryan Bishop posted full transcripts of the Decentralized Financial Architecture 2019 workshop (Bitcoin Edge), covering custody, compliance, confidential transactions (Beam), and regulatory perspectives from Japan’s Financial Services Agency; links are archived at diyhpluswiki.  
- ICANN policy documents on DNS abuse and a pre-ICANN65 policy report were circulated, though no deep technical discussion followed.  
- A side thread considered whether global-cooling-driven shifts in warm-water port viability (e.g., St. Petersburg, Novorossiysk) could form the basis of targeted real-estate shorting strategies, contingent on multi-factor market analysis rather than temperature alone.