- **Programmable quasicrystals** were proposed as a potential long-term storage (LTS) writing mechanism once their growth can be better controlled, with a noted trade-off between stability and energy cost for writing data.

- **Bio-engineered silkworm silk** was discussed for diverse applications: trace-chemical color-changing proteins, heavy-metal ion binding, antibacterial surgical sutures, and 3-D-printed organoid scaffolds with embedded tissue-specific growth factors, tempered by the constraint that the silk must still function in the worm’s molting process.

- **Neural simulation and AGI architectures** were debated, referencing the Nengo/SPAUN framework, Ted Berger’s hippocampal prosthesis, and the argument that declarative long-term memory, working-memory buffers, reinforcement-learned procedural patterns, plus perception/motor modules may suffice for general intelligence.

- **Gene-therapy delivery** questions arose around infusing the protective APOE2 gene into cerebrospinal fluid—whether via viral vectors, naked DNA, or small RNA fragments that cells might spontaneously uptake.

- **Mars mission architecture** discussion compared Elon Musk’s full-scale Starship plan with Robert Zubrin’s “mini-Starship” concept, weighing mass budgets, reusability, and the practicality of stripping early ships for on-site material use versus returning them to Earth.

- **Lunar infrastructure ideas** included a lunar space elevator feasible with current materials (≈42 m³ cable volume), rotating momentum-exchange tethers to sling payloads from the Moon to Earth orbits, and the prospect of using lunar-derived hydrocarbons for methane-based lunar landers.

- **Molecular CAD/CAM pipeline** needs were highlighted: lsneff is reimplementing NanoEngineer and seeks a manufacturing-oriented data model; fenn referenced prior work on specifying construction pathways for mechanical structures.

- **Recent research links** shared: PNAS paper on a single combination gene therapy treating multiple age-related diseases, biorxiv study on minimal cognitive architectures, and arxiv papers on grammar-guided neural program synthesis and programmatically interpretable reinforcement learning.