- **CRISPR pain editing**: Wired article discussed using CRISPR to abolish human pain; channel members debated whether chronic pain is useless and should be eliminated, while acute “actionable” pain is valuable for injury detection.

- **EPAS1 high-altitude allele**: Sherpa-derived EPAS1 variant prevents altitude-induced blood thickening; added to the open “genetic-modifications” wiki as a candidate CRISPR enhancement for space or high-altitude living, with caveats about stroke risk and sudden hypoxic death.

- **DIY SNPedia mirror**: fenn reported that the automated SNPedia dump script (dumpgenerator.py) is failing; plans to switch to manually exporting every page title via MediaWiki’s Special:Export to maintain an offline copy.

- **Germinal choice ethics**: kanzure posted excerpts from Gregory Stock’s 2005 paper arguing that universal access to germinal choice technology (GCT) will erode elite genetic advantages and force society to redefine “meaningful life,” equality, and coercion versus parental autonomy.

- **Omnigenic model**: Quanta Magazine article linked showing that essentially all genes influence every complex trait, underscoring the difficulty of simple enhancement edits and reinforcing the need for systems-level genetic design.

- **Micro-scale particle accelerator**: TechCrunch coverage of a pin-head-sized particle accelerator noted as a potential future tool for targeted radiotherapy or in-vivo genetic engineering.

- **Ectogenesis definition**: term explicitly looked up and discussed as the technology for ex-vivo human gestation, relevant to artificial-womb research and reproductive autonomy.

- **Transhumanist blind spot**: kanzure laments that most transhumanist literature is AI-centric and dystopian; calls for more bio-oriented, optimistic visions of “how good can good get” without relying on machine superintelligence as deus-ex-machina.

- **Abundance thesis**: reference to Diamandis & Kotler’s “Abundance: The Future Is Better Than You Think” used to counter Malthusian pessimism, arguing technological progress can outpace resource limits.

- **DIY bio repository**: diyhpl.us/wiki/genetic-modifications/ maintained as a living list of candidate human enhancements (EPAS1, PDE10A large-spleen diving trait, etc.) open for community edits and technical vetting.