- The channel debated the safety profile of MAOIs (monoamine oxidase inhibitors) marketed as nootropics, with jrayhawk noting that MAO-B-selective inhibitors (e.g., selegiline, l-deprenyl) are “somewhat less threatening” than non-selective MAOIs, while fenn questioned the danger level of mild plant-derived MAOIs such as ginkgo and curcumin.

- Participants listed everyday substances claimed to have MAOI activity—chocolate, kava, licorice root, green tea, turmeric—prompting a literature check that found only weak or animal-only evidence for most of them.

- A NEJM review (https://www.nejm.org/doi/full/10.1056/NEJMra1905136) was shared, summarizing evidence that an 18-hour fast/6-hour eating window triggers a metabolic switch from glucose to ketone energy, allegedly increasing stress resistance and longevity while lowering cancer and obesity incidence; kanzure questioned whether the timing should scale with individual glycogen stores.

- Discussion of stimulant regulation compared caffeine’s “awful side-effect profile” (jrayhawk) to amphetamines, with maaku proposing either pharmacist-controlled dispensing or adding an emetic to deter recreational over-use.

- Links to futurist media were posted: the short film “Welcome to Life: the singularity, ruined by lawyers” (https://youtu.be/IFe9wiDfb0E) and its inspirations—Jim Munroe’s “Everyone in Silico” and Rudy Rucker’s “Postsingular”—as well as a Reddit thread on Vitalik Buterin’s views on Bitcoin, immortality, and finance.

- Elon Musk’s stated motivation for funding Neuralink—“to make it more likely humans will survive the singularity”—was highlighted.

- NAD+ precursors NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) were introduced; heath provided an Elysium Health explainer (https://www.elysiumhealth.com/en-us/knowledge/science-101/nmn-and-nr-how-these-nad-precursors-measure-up) and fenn noted that NMN is simply an alternative formulation of vitamin B-3.