- DeepMind’s AlphaFold breakthrough for protein-structure prediction was highlighted, including the open-source “ProSPr” re-implementation (https://github.com/dellacortelab/prospr) and the release of DeepMind’s own CASP13 code (https://github.com/deepmind/deepmind-research/tree/master/alphafold_casp13).  
- A community “Protein Engineering Wishlist” was drafted and iteratively expanded on the DIYH+ wiki (http://diyhpl.us/diyhpluswiki/protein-engineering/), covering long-tube “molecular factory” proteins, modular polyketide and non-ribosomal peptide synthases, and enzyme clustering for metabolic channeling.  
- The European Patent Office formally revoked a key Broad Institute CRISPR patent, signaling ongoing global IP reshuffling for CRISPR-Cas systems (https://www.juve-patent.com/news-and-stories/cases/epo-revokes-broad-institute-patent-but-its-just-the-beginning-for-crispr-cas/).  
- Cardiff University researchers reported a new MR1-restricted T-cell clone that targets a wide range of cancer cells, raising the prospect of a “universal” T-cell therapy (Nature Immunology paper: https://www.nature.com/articles/s41590-019-0578-8).  
- Discussion of Mars settlement logistics included Casey Handmer’s blog post on working conditions on Mars (https://caseyhandmer.wordpress.com/2020/01/20/what-would-it-be-like-to-work-on-mars/) and debate over whether radiation risks are overstated; simple regolith shielding (sandbags or ~27 m of rubble) was proposed as an adequate countermeasure.  
- Bitcoin-related technical links covered electrochemical machining of gun barrels, Lightning-dev speculation on hardware-wallet support, new btcdeb features for script debugging, and the social argument that conferences costing thousands in attendee time should budget ~$60 for professional transcripts.