- A mechanistic hypothesis was debated that wheat-derived gliadin peptides increase intestinal and blood–brain barrier permeability via CXCR3, supported by cited RCTs showing reversal of autoimmune and metabolic-syndrome markers on grain-free diets.  
- Participants proposed a dopamine-centric model of ADHD sub-types: hyperactive as low tonic/phasic dopamine signal-to-noise, inattentive as global dopamine deficit, with COMT Val158Met and TAAR1 activity as key modulators, and linked MTHFR A1298C polymorphisms to inattentive-type ADHD.  
- Harold Katcher’s non-cell-autonomous theory of aging—based on heterochronic transplantation and iPSC reprogramming—was contrasted with the “damage accumulation” paradigm, while the mitochondria-derived peptide Humanin and its potent S14G analogue (HNG) were discussed as cognition-enhancing, insulin-sensitizing rejuvenation factors.  
- A speculative “iterated selection of implanted organoids” protocol was outlined: serial in-vivo implantation, vascularization, screening, and evolution of organoids to discover rejuvenative factors, optionally accelerated by mutagenesis between cycles.  
- Google released OpenSK, a fully open-source FIDO2 security-key firmware for Nordic nRF52840 dongles, available at https://github.com/google/OpenSK.  
- Battery-life constraints were identified as the primary barrier to 24/7 wearable audio logging; continuous Apple Watch recording drains by mid-afternoon, whereas an 8-hour offline Chinese recorder lacks real-time processing.  
- Dream engineering techniques were shared, including galantamine for vividness and dream recall, anecdotal “sleep-typing” experiments, and evidence of motor output (signing) during REM in deaf individuals.  
- Data longevity warnings were voiced after superkuh lost years of notes to a proprietary rich-text app, reinforcing the channel’s consensus for plain-text notes under version control; jrayhawk cited a 2 PB Google-Drive archive as an extreme personal data-hoarding example.