• A DIY vacuum-deposition controller and associated hardware were showcased in an Imgur album, illustrating grassroots thin-film fabrication capabilities relevant to micro-electronics and bio-sensor prototyping.  
• Discussion of a new CRISPR article (longevity.technology) prompted skepticism about a claim that “femtoliter” volumes (10 L) can be injected into single mammalian cells; participants noted that conventional micro-injectors already achieve sub-picoliter delivery for CRISPR experiments.  
• A detailed open-science proposal for COVID-19 therapy was presented: simultaneous siRNA knock-down of both ACE and ACE2 combined with inhalation delivery of angiotensin 1-7 and 1-9 peptides to block viral entry while compensating for lost enzymatic activity.  
• Practical challenges to the siRNA/peptide concept were raised, including mismatched half-lives (siRNA persists days, peptides minutes), potential compensatory overexpression of target genes after RNAi decay, and the absence of mice with fully humanized pulmonary ACE2 for SARS-CoV-2 studies.  
• The proposer sought BSL-3 or equivalent facilities—especially in “less-regulated” regions—capable of infecting chimpanzees or humanized mice to test the treatment; channel members advised starting with toxicity studies in normal animals first.  
• A Bitcoin-focused transcript of Pieter Wuille (Chaincode Labs, Jan 2020) was added to the diyhpluswiki, expanding the archive of open-source cryptocurrency and decentralized-systems discourse.