- A Nature Protocols paper on “Solid-state nanopore fabrication by automated controlled breakdown” was highlighted; the method achieves >85 % yield of low-noise nanopores and can be reproduced with fully open-source hardware/software, although the original authors used Windows and closed SLA printers.  
- CaptHindsight shared the supplementary materials ZIP (41596_2019_255_MOESM5_ESM.zip) to facilitate replication of the nanopore protocol.  
- Discussion of misleading “nm” node marketing in semiconductor fabrication: participants noted that the quoted nanometer value refers to minimum feature size, not actual transistor or gate dimensions, and advocated reporting transistors per mm² instead.  
- TSMC’s announcement that it has begun developing a 2 nm process (with 3 nm already in progress) was linked, prompting the above critique of node naming conventions.  
- kanzure posted a technical write-up on “multiparticipant coinswap” (https://zmnscpxj.github.io/bitcoin/multiswap.html) for improving Bitcoin transaction privacy.  
- lsneff recommended Bret Victor’s 2013 talk “The Future of Programming” (Vimeo 71278954) and provided a full transcript link; fenn summarized the core message as “parallel computing” and contrasted it with Henry Lieberman’s “Programming by Example” approach documented at MIT (http://web.media.mit.edu/~lieber/Your-Wish-Intro.html).  
- Conversation about interoperability lamented the complexity of modern protocol stacks (JSON/HTTP2/TCP/UDP) and language-version mismatches; Wasm “interface types” were proposed as a promising abstraction for sharing rich data across language boundaries without dictating internal representation.  
- L29Ah shared a PubMed study on methylene blue (PMID 21454572) and noted its 2-hour half-life; fenn cautioned that its role as an oxidative radical generator makes short duration desirable.  
- TMA raised the question of survivor bias in “optimism vs. pessimism” literature, wondering what proportion of persistent optimists ultimately fail and whether empirical data exist beyond stock-market studies.