- A paper on protein oligomer engineering (“Better together…”) was cited, noting that ~25 % of prokaryotic proteins ≥500 aa contain substitution errors and ~1/7 are prematurely released from the ribosome, highlighting quality-control limits for synthetic-protein nanostructure projects.  
- Participants questioned whether “protein molecular-lego” cross-linkers can actually build polyhedral nanobricks in practice, observing that no convincing demonstrations exist so far.  
- A request was made for a curated list of “important things to do with polyhedral DNA origami,” indicating interest in systematic applications beyond simple shape construction.  
- The 2010 Nature paper “A proximity-based programmable DNA nanoscale assembly line” (PMC2872101) was shared as a reference for DNA-guided molecular manufacturing.  
- Skepticism was voiced about the “DNA robot arm” concept (Maaku’s cited 2018 Science paper on electric-field-controlled robotic arms), specifically regarding its utility for bootstrapping more advanced molecular machines.  
- A link to an archived PDF of “Engines of Creation 2.0” (circa 1988) was posted, suggesting renewed attention to Drexler’s foundational roadmap for molecular nanotechnology.  
- Sci-Hub’s new PGP key was noted, reflecting ongoing reliance on the platform for open access to pay-walled research.