- A 2013 paper on synthetic ribosomes was highlighted, describing a rotaxane-based artificial small-molecule machine that can perform sequence-specific peptide synthesis by plucking amino acids from a pre-assembled rod and forming peptide bonds—an alternative to fully protein-based ribosomes.  
- Discussion of the practical limits of diamondoid, atomic-precision nanotechnology emphasized that at room temperature thermal motion (~GHz) makes positional control of individual atoms unreliable; biology’s “squishy” chemistry and weak bond strengths were contrasted as more viable for scalable molecular manufacturing.  
- Error rates in biological information transfer were reviewed: DNA ≈10⁻⁹, RNA ≈10⁻⁵, protein synthesis ≈10⁻⁴ errors per residue, with RNA viruses accumulating multiple transcription errors per virion—underscoring the need for error-correction or tolerance mechanisms in any synthetic biology approach.  
- The open-source “dnastore” project (GitHub: ihh/dnastore) was introduced—software that uses finite-state transducers to encode digital data into DNA sequences with error tolerance, illustrating ongoing work in DNA-based archival storage.  
- A 3-D printing study (Liebert, 2019) was noted for producing modular protein-backbone components as physical hand models, demonstrating how additive manufacturing can accelerate design–build–test cycles in protein engineering.  
- Links to transcripts of recent Bitcoin technical meetups (LA BitDevs on Segwit/PSBT vulnerability and Sydney Socratic Seminar) were added to the diyhpl.us wiki, showing the channel’s parallel interest in open-source security and cryptocurrency infrastructure.  
- The “Human Programming Interface” blog (beepb00p.xyz/hpi.html) was recommended for its novel ideas on self-quantification and personal software augmentation, reflecting the community’s broader exploration of tools for cognitive enhancement.