- A curated archive of open-access papers on DIY DNA synthesis is available at http://diyhpl.us/~bryan/papers2/DNA/ and https://diyhpl.us/wiki/dna/synthesis/notes/, covering phosphoramidite chemistry, error-correction strategies, and the practical gap between making short PCR primers versus full-length gene synthesis.

- Participants debated the feasibility of a truly “garage-level” DNA synthesizer, concluding that while phosphoramidite chemistry itself is straightforward if reagents are purchased, achieving the 99.9999 % stepwise yields needed for error-free genes remains the major hurdle.

- A hypothesis was advanced that a large share of chronic fatigue, ADHD, and treatment-resistant mental-health issues may stem from under-diagnosed sleep-disordered breathing (especially UARS and NREM instability), with craniofacial dystrophy driven by modern diets proposed as a root cause.

- Discussion linked menstrual-cycle–dependent airway resistance to the observed 2:1 male-to-female ratio in UARS studies, suggesting women are under-detected because diagnostic testing is not synchronized with hormonal phases that worsen obstruction.

- Future open-hardware plans were outlined for an inexpensive, easy-to-build bilevel PAP device to broaden access to therapy in regions where commercial devices are restricted or unaffordable.

- A new pre-print on peptide “antidotes” to SARS-CoV-2 (https://www.biorxiv.org/content/10.1101/2020.08.06.238915v2) was critiqued for claiming micromolar affinities and for misinterpreting competitive inhibition of neutralizing antibodies as an immune-evasion mechanism.

- Side topics included a $4 k telepresence robot (Double Robotics) that participants would like to replicate DIY, and a Hacker News anecdote about booting 1970s computers by manually yanking a high-tensile-strength plastic tape through a reader at maximum speed.