- Primary cilia are being re-evaluated as sensory “antennae” in neurons; new rat-brain imaging shows dense cilia in post-natal cortex and an upcoming preprint from Sengupta & Turrigiano labs will detail their functional roles.  
- A biorxiv preprint demonstrates automatic segmentation of 35 organelles and macromolecular structures in whole-cell FIB-SEM volumes at 4–8 nm isotropic resolution, enabling large-scale connectomics and ultrastructure mapping.  
- BEAM-201 base-editing therapy achieves four simultaneous in-vivo gene edits in human T cells, shown in a Beam Therapeutics video; the approach is framed as a step toward multiplexed, precise cellular reprogramming.  
- “TRAFTACs” (Transcription Factor Targeting Chimeras) are introduced as a targeted-protein-degradation platform for transcription factors, expanding the molecular toolbox beyond PROTACs.  
- In-vivo mRNA display coupled to next-generation sequencing is presented as a high-throughput method for surveying protein–ligand interactions across entire proteomes.  
- A Cell Stem Cell paper reports partial epigenetic reprogramming (Yamanaka factors delivered transiently in vivo) that reverses aging markers in dentate-gyrus neurons and improves memory in aged mice.  
- DRACO (Double-stranded RNA Activated Caspase Oligomerizer) is highlighted in an Open Philanthropy informal write-up as a broad-spectrum antiviral candidate that triggers apoptosis in infected cells.  
- Discussion of “The Great Stagnation” (Tyler Cowen, 2011) versus J. Storrs Hall’s “Where Is My Flying Car?” frames technological slowdown not as exhausted low-hanging fruit but as institutional and energetic bottlenecks; a user-generated list of 1990s-viable missed opportunities (e.g., Teledesic, prefab housing, supersonic flight) is shared.  
- IBM’s neuromorphic “brain-inspired” chip and the Izhikevich simple spiking-neuron model are cited as hardware-friendly substrates for large-scale neural emulation.  
- Links to open-source security guides (Michael Flaxman transcript), a Milwaukee ¼-inch impact partial-hand prosthetic demo, and a 1990s sci-fi film “W.E.I.R.D. World” (featuring foreskin grafts and bat-virus outbreaks) are circulated as cultural/technical curiosities.