• GPT-3 is now offered as a cloud-only API via ShortlyRead.com, reigniting debate over the inevitability of cloud-centric software and the loss of local, offline alternatives for advanced AI tools.  
• Participants framed the issue as a systemic, statistical-mechanics problem: individual choices aggregate into market trends that push all software toward network dependency, making personal opt-outs statistically insignificant.  
• DeepMind’s AlphaFold breakthrough was highlighted, with links to the official announcement, an open-source re-implementation (ProSpr), and a PNAS paper on using predicted inter-residue orientations to improve structure prediction.  
• A PubMed paper on ultrasound-activated nanoparticles delivering CRISPR/Cas9 for androgenic alopecia therapy was shared, prompting surprise that in-vivo gene editing via acoustic targeting is already feasible.  
• An open-source all-iron battery design for renewable-energy storage was circulated (ScienceDirect article), adding to the channel’s collection of DIY-friendly energy tech.  
• Technical teardown of Starlink’s consumer phased-array antenna revealed a “reactive impedance surface” metasurface isolating circular patch elements plus suspended director layers, simpler than some had expected.  
• Bryan Bishop posted the transcript of a Bitcoin Socratic Seminar held in San Francisco, continuing the channel’s practice of archiving open-source finance and cryptography discussions.