- Ultra-low-current nanopore sensing: nmz787 is running a trans-impedance amplifier + ADC front-end based on the TI LMP7721 op-amp, achieving ~picoamp resolution over a ±250 nA range.  
- Charge-integration alternative: discussion referenced the TI IVC102 precision integrating amplifier and a 2014 paper (Scitepress 47868) that use switched-capacitor feedback and periodic charge-reset to avoid very large feedback resistors.  
- PCB flexure actuators: lsneff is exploring FR4 and flex-rigid PCBs as ultra-low-cost substrates for 3-DOF micro-actuators; compliant hinges are created by selective milling or partial drilling.  
- Supporting literature: two papers were located—an electromagnetically-actuated FR4 scanner (Ku Univ.) and an “energy-harvesting” FR4 cantilever (IOP 2012), both showing PCB-compatible compliant mechanisms.  
- USAF AI milestone: Artuμ, a modified μZero gaming algorithm, was flown as the first AI copilot/commander aboard a U-2 spy plane, controlling the radar during a training mission.  
- Anti-aging VC interest: Steve Jurvetson (long-time transhumanist backer) is publicly shifting focus toward longevity and tweeting skepticism about patents’ role in innovation.  
- SpaceX SN8: fenn linked what is described as the highest-quality public footage of the Starship SN8 launch, belly-flop maneuver, and landing explosion.  
- Steam-rocket fatality: Flat-Earth daredevil “Mad Mike” Hughes died in a crash of his home-built steam-powered rocket, highlighting fringe rocketry risks.