- COVID-19 risk discussion: participants debated the difference between “case fatality rate” (CFR) and “infection fatality rate” (IFR), noting that CFR is biased toward severe cases because only symptomatic or tested individuals are counted; South Korea’s CFR stayed stable while Italy’s early CFR was ~1.6 % for under-49s but later improved 3–5× due to better testing and care.  
- Data sources shared: Our World in Data CFR-by-age charts (http://ourworldindata.org/mortality-risk-covid) and CDC weekly death tables were used to illustrate how testing volume and medical capacity alter apparent risk.  
- Home genomics feasibility: superkuh asked whether an Oxford Nanopore MinION is now sufficient for a moderately-resourced individual to sequence their own genome; nmz787 cited Sebastian Cocioba’s home plant lab as evidence it is possible, emphasizing that high-quality sample prep (to reduce DNA shearing) is the critical bottleneck.  
- E-ink hardware news: kanzure linked a Reddit thread announcing Dasung’s new 25-inch e-ink monitor; participants complained that e-ink progress has been slow, attributing it to e-ink Corp.’s monopoly and consequent stagnation.  
- DIY transcript repository: gnusha bot announced several new transcript additions to diyhpluswiki, including Christopher Jeffrey on Bitcoin consensus and Matt Corallo on BetterHash, expanding the open archive of technical talks.  
- Cross-language interface tooling: lsneff proposed that tooling analogous to WebAssembly Interface Types (https://github.com/WebAssembly/interface-types/blob/master/proposals/interface-types/Explainer.md) should exist for native libraries, enabling rich, language-agnostic type signatures between Rust, C++, and other compiled languages; fenn pointed to related Haskell work and idiomatic-monads-in-Rust explorations.