• A user is reverse-engineering the control software of a Seiko Instruments FIB microscope, discovering undocumented service passwords via string dumps and patching 68 k assembly code; the microscope runs Microware OS-9 and the SDK is available at https://github.com/HoldcroftJ/os9_68k_sdk_v12.

• The sandsifter/xoreaxeaxeax tool was praised for its clever method of brute-force discovery of undocumented x86 instructions by observing fault types when instructions cross page boundaries, offering a practical way to infer instruction length.

• Participants discussed extending American Fuzzy Lop (AFL) to bit-level mutations (afl-smart) for non-byte-aligned file formats, contributed by a hardware-security-researcher spouse, highlighting ongoing open-source fuzzing innovation.

• Practical air-gap and compartmentalization strategies were explored, including separate physical machines, literal KVM switches, HDMI capture for video, and data-diode or netcat-based text transfer to keep a “secure” box offline after software installation.

• Josiah Zayner’s CRISPR educational kits and biohacker classes were delisted by Facebook under “services may not be listed” policy, with YouTube also deplatforming him, illustrating ongoing tensions between biohacking education and platform content policies.

• Participants debated whether transhumanism exhibits religious characteristics, particularly the “promised afterlife” of cryonic preservation at Alcor, referencing the TV Tropes page “No Such Thing as Space Jesus” and invoking the phrase “I know it when I see it” to critique definitional challenges.

• The historical example of Konstantin Tsiolkovsky—who derived foundational astronautics theory while living in a remote log cabin—was highlighted as an inspirational case of individual, low-resource scientific breakthroughs relevant to DIY and open-source transhumanist experimentation.