- Ciphey, an open-source tool for automatic decryption, encoding detection, and hash cracking without prior knowledge of keys or ciphers, was highlighted; its supported-cipher list is documented at https://github.com/Ciphey/Ciphey/wiki/Supported-Ciphers.  
- nmz787 shared a teardown photo of an early-generation ABI 391 DNA synthesizer, noting its large empty internal volume and linking to the manual at http://diyhpl.us/~bryan/papers2/DNA/abi391/takeitapart/reasonable-size/394wTUS.jpg.  
- Discussion of a new George Church–backed AAV gene-therapy venture that reportedly reduces immune responses to viral vectors by inserting telomeric TTAGGG repeats into the vector DNA, exploiting the immune system’s tendency to ignore DNA containing such “self” sequences.  
- yashgaroth explained that the technique—sprinkling telomeric repeats into plasmid or vector DNA to suppress innate immune activation against unmethylated CpG motifs—has been used for decades, casting doubt on the novelty of the company’s approach.  
- lsneff introduced Dyndride, a startup claiming a GPU-accelerated geometry kernel for CAD; participants criticized its scant “whitepaper” (https://exhibitorsearch.messefrankfurt.com/images/original/userdata/bata/214803/5d72eff7b467e.pdf) as a sales brochure overly focused on 3-D printing and lacking detail on constraints, optimization, or traditional CAD features.