- CRISPRoff paper (Cell 2021, doi:10.1016/j.cell.2021.03.025) introduced as a programmable methylation-reprogramming tool; channel members seek the full manuscript and note that the press coverage omits which methyltransferase is actually used in the system.  
- Discussion of reversible methylation: kanzure points to TET1 (ten-eleven translocation 1) as a known DNA demethylase and notes that Cas9-TET1 fusion proteins already exist, providing a CRISPR-based route for targeted demethylation.  
- L29Ah reports a four-day self-experiment with GHRP-6 (growth-hormone-releasing peptide-6), highlighting practical downsides—daily injections, anxiety over scarring, and general dissatisfaction with peptide administration logistics.  
- DIYHplusWiki updated with a new page on “the other CRISPRoff” (not the light-activated variant) to archive technical details and links for open-source gene-editing researchers.