- **Ketone bodies as a brain-energy rescue pathway**: A participant synthesized literature arguing that ketones (β-hydroxybutyrate, acetoacetate) restore network stability and synaptic plasticity in brains compromised by aging, insulin resistance, or sleep-disordered breathing, and that exogenous ketone supplementation (C8 oil, BHB salts/esters, 1,3-butanediol) reproduces the cognitive and metabolic benefits of fasting without weight loss.  
  – Supporting links: PMC7084077, PMC4212005, and a personal literature digest at https://gist.github.com/Asmageddon/f9b26ebc70aa7487153467d8f2130249.

- **Practical ketogenesis hacks discussed**: C8 (caprylic) triglyceride oil taken 2–3 times daily was proposed as the simplest non-fasting route to sustained blood ketones; 1-octanol was noted as a cheap solvent that metabolizes to C8 but causes transient oral paresthesia; curiosity was expressed about lysophosphatidylcholine-C8 as a brain-selective ketone shuttle.

- **PPAR-agonists and metformin as indirect ketogenic agents**: PPAR-α/γ agonists (e.g., fibrates, thiazolidinediones) were mentioned for up-regulating lipolysis and hepatic ketogenesis, while metformin was suggested for its mild ketogenic effect via AMPK activation.

- **Debate on saturated-fat safety**: One participant argued that RCT evidence from the 1970s–80s (Finnish mental hospital, LA VA, Sydney Diet Heart) shows saturated fat reduces all-cause mortality except in individuals with ApoE4 homozygosity or familial hypercholesterolemia, and criticized the AHA stance as industry-driven; links to Dayton-Pearce 1969 and Ramsden 2013 papers were provided.

- **Iodine supplementation as longevity prep**: A 100 g bulk purchase of NaI (≈1,546-year supply) was rationalized as both radioprotective and a hedge for extreme life-extension scenarios.

- **Vaccine-myocarditis and fertility concerns**: Discussion cited Ontario data (≈1:3000 teenage males) and spike-protein biodistribution studies to question the risk-benefit balance of vaccinating low-risk children, arguing that early unblinding of trials and political incentives degraded long-term safety epistemology.

- **Neuroscience links shared**:  
  – Brain Initiative Cell Census Network collection (nature.com/collections/cicghheddj) for single-cell brain atlases.  
  – Hawkins & Ahmad 2015 arXiv paper “Why Neurons Have Thousands of Synapses” proposing a biologically plausible sequence-memory model for neocortical neurons.  
  – Observation that C. elegans neurons operate with more sub-threshold analog processing than mammalian spiking neurons.