- A 2010 thesis on “high-throughput plasmonic nanolithography” was circulated; it describes arrays of plasmonic “lenses” that shrink optical spots to ~30 nm, mounted on a hard-drive head flying 2 nm above a spinning wafer and synchronized with picosecond-pulsed lasers for desktop-scale sub-30 nm photolithography.  
- Links to open-access papers on low-cost microfluidics were shared, including toner-printed “Shrinky-Dink” polystyrene chips, single-sided opto-electrowetting (SCOEW) droplet manipulation with LCD light patterns, and massively parallel single-cell handling via DMD mirrors.  
- Participants debated practical entry costs for DIY DNA synthesis: ~US $3 k in reagents (DNA phosphoramidite monomers at ≈US $5 g⁻¹ in 100 g lots) plus similar equipment costs, with group buys suggested to amortize shipping and chemical expenses.  
- Recent Nature and Aging Cell papers on in-vivo partial reprogramming were posted, showing that a single cycle of transient Yamanaka-factor expression can reverse age-related molecular signatures in naturally aged mouse tissues.  
- Discussion of open-source CAD geometry engines included a new B-rep/NURBS kernel announced on Hacker News and the difficulty of adding slicing support inside FreeCAD.  
- Electrochemical 3-D printing (mentioned from an earlier patent) was proposed as a route to fabricate nano-imprint lithography templates, with links to Kragen’s notes on electrochemical machining and fresnel-mirror electropolishing.