- A PNAS paper demonstrated the first live mammalian offspring produced from single unfertilized oocytes by rewriting DNA methylation at seven imprinting control regions using dCas9-Dnmt3a and dCpf1-Tet1 mRNA plus sgRNAs; viable full-term pups were obtained in highly inbred lab mice.  
- Discussion framed this as a potential tool for “designer babies” if in-vitro culture disturbs imprinting, and clarified that the method uses pre-meiotic oocytes, yielding offspring genetically identical to the mother but with chromosomal recombination between homologous pairs.  
- Participants debated the practical limits of ADHD pharmacotherapy: rapid tolerance build-up, side-effect burden, and the strategy of taking drug holidays to maintain efficacy were highlighted, with one user noting diagnosis came incidentally from recounting educational history rather than intentional pursuit.  
- Career advice cautioned against entering machine-learning research at “peak hype,” favoring space-related fields; a counterpoint joked that the same warning could apply to blockchain.  
- Russia’s announced suspension of ISS cooperation until Western sanctions are lifted was dismissed by one member as political theater masking an already failing space program.