• The channel debated whether large-scale quantum computing (QC) is essentially impossible without atomically precise manufacturing (APM), arguing that APM’s ability to place single phosphorus dopants with STM/HDL lithography is the only route to the low-error, scalable qubit arrays required for real-world quantum computers.

• A 2022 Zyvex Labs white-paper was cited showing that STM-based hydrogen-depassivation lithography can create regular nanoscale arrays of phosphorus donors in silicon, directly addressing the spatial scatter problem that plagues ion-implanted devices and enabling 2-donor-gate interactions needed for error-corrected QC.

• Participants noted that the primary commercial driver for QC development may not be chemistry or optimization but the cryptographic bounty of cracking Bitcoin wallets—joking that Satoshi’s untouched coins could become a lucrative “philanthropic” prize for the first scalable quantum computer.

• Zyvex’s commercial status was dissected: the firm was split in 2007 into Zyvex Performance Materials (carbon-fiber additives), Zyvex Instruments (now owned by Thermo Fisher for nanoprobe IC testing), and Zyvex Labs (government-funded R&D); current STM lithography tools such as the “ZyVector” platform are available for purchase, yet the business model still relies on SBIR/STTR contracts rather than volume sales.

• Discussion of near-term QC utility concluded that even quadratic speedups (e.g., Grover’s algorithm) are offset by huge constant-factor slowdowns in present devices; APM-based fabrication could reduce error-correction overhead enough to make quantum advantage practical for real-world problems.

• Spiroligomer chemistry received attention: a new Org. Lett. paper detailed Fmoc-protected bis-amino acid building blocks synthesized at multi-kilogram scale, enabling automated solid-phase assembly of highly rigid, non-flailing molecular scaffolds that could serve as enzyme-like catalysts or nanoscale frameworks.

• The U.S. Department of Defense extended funding for spiroligomer research by an additional 18 months, underscoring military interest in programmable, atomically precise materials.

• Practical pharmacology notes were shared on volumetric micro-dosing of Vyvanse (10 mg vs 30 mg) to avoid extended-release commitment, highlighting self-experimentation culture in the channel.

• Links of note: Zyvex APM overview (https://www.zyvexlabs.com/apm/rd/science-of-apm/), SBIR award for high-speed STM lithography (https://www.sbir.gov/node/2151579), and a 2022 video update on Zyvex capabilities (https://youtu.be/TC5I-q5Wuik).