- GP-write Startup Team launched an RFP offering up to $500 k plus mentorship for startups working on genome-scale design software, DNA synthesis tools, precision genome editing, or chromosomal/organism engineering; proposals are due 1 July 2022.  
- Participants debated whether HTML5 is a genuine standard or an ever-shifting blob controlled by big vendors, and whether its cross-platform “write once, run anywhere” advantage outweighs the performance and complexity costs for immersive 3-D or game-like applications.  
- The conversation contrasted lightweight protocols such as Gopher and terminal-based browsers (links2, w3m, dillo) with the modern web stack, praising the former for speed, simplicity, and absence of JavaScript bloat.  
- MimbleWimble was introduced as a blockchain privacy protocol that hides transaction graphs; kanzure linked a Dragonfly Research post detailing recent attacks that undermine its anonymity guarantees.  
- Web3 skepticism was voiced: participants questioned why ordinary users would want all transactions permanently logged and saw most Web3 projects as resource-wasting scams.  
- A historical thread recalled early-1990s internet culture when shared VAX machines were “racehorses” tended by dedicated staff, contrasting with today’s “cattle, not pets” cloud paradigm of disposable containers.  
- Cost-of-computing discussion: a minimal microcontroller capable of TCP/IP can be built for roughly US $0.50, while a usable full system (with display and input) still approaches a week of minimum-wage labor.  
- Personal productivity themes emerged: fenn described how adopting systematic “fishtubs”-style organization after 2005 improved conscientiousness but created an ever-growing implicit todo list that now causes stress and perceived cognitive decline.