- Explored the idea of a human “cloaca” (single combined outlet for digestive, urinary, and reproductive tracts) as a speculative transhumanist body-mod, weighing potential benefits such as fewer orifices, lower risk of rectovesicular fistulas, and a urine-flush “self-cleaning” effect versus drawbacks like mismatched sphincter requirements for solids vs. liquids and higher kidney-infection risk.  
- Discussed practical intermediate hacks like simply redirecting the urethral opening toward the anus to create a built-in bidet while preserving an air-gap barrier against infection.  
- Noted that cloaca-bearing animals (birds, reptiles) produce solid urate “bird slice,” illustrating how urinary state influences anatomical feasibility.  
- Linked the conversation to broader themes of human genetic engineering via a tweeted provocation: “What if we did widespread human genetic engineering and it turned out fine?” (@mattparlmer).  
- Highlighted the cultural framing of such bio-radical ideas through tongue-in-cheek references to “genetically engineered two-assed Kardashians,” underscoring the channel’s mix of technical depth and irreverent humor.